v Share Your Health

Lead Exposure May Contribute to ADHD

TUESDAY, Feb. 2 (HealthDay News) — Lead may play a role in the development of attention-deficit hyperactivity disorder (ADHD), new research suggests.

Genes are believed to account for as much as 70 percent of ADHD in children. Researchers trying to determine the cause of the other 30 percent of cases consider lead a prime suspect among possible environmental causes, according to the American Association of Psychological Science.


Lead, a neurotoxin, is present in trace amounts in such things as soil, drinking water, children’s costume jewelry and imported candies. Nearly all children in the United States have measurable levels of lead in their bodies, the association reports.

In one of two recent studies examining the possible link between lead and ADHD, the researchers found that children with ADHD had slightly higher levels of lead in their blood than did children without ADHD. The second study showed an association between elevated levels of lead in children’s blood and parent/teacher ratings of ADHD symptoms, including both hyperactivity and attention problems.

In both studies, the link between lead and ADHD was independent of the children’s IQ, family income, race or whether their mothers had smoked during pregnancy.

The findings strongly suggest that lead may be a cause of ADHD, according to Joel Nigg, a psychological scientist at Oregon Health & Science University. He said that lead might disrupt brain activity in a way that leads to hyperactivity and attention problems.

The studies are published in the February issue of the journal Current Directions in Psychological Science.

More information

The U.S. National Institute of Mental Health has more about ADHD.

— Robert Preidt

SOURCE: Association for Psychological Science, news release, Jan. 28, 2010

Last Updated: Feb. 02, 2010

Copyright © 2010 HealthDay. All rights reserved.

Folate Levels in Pregnancy Tied to ADHD in Offspring

TUESDAY, Nov. 3 (HealthDay News) — Low folate levels during pregnancy are associated with higher odds for attention deficit hyperactivity disorder in offspring aged 7 to 9, new research has found.

The findings seem to support the long-held belief that folate (folic acid) levels in expectant mothers influence their children’s nervous system development.


The researchers also found that children of mothers with low folate levels had notably smaller head circumference at birth, which may indicate a slower rate of prenatal brain growth.

The study was released online Oct. 28 in advance of publication in an upcoming print issue of the Journal of Child Psychology and Psychiatry.

“Our findings further support the hypothesis that maternal nutrition contributes to an individual’s development, with potential consequences for their behavior later in life,” study author Wolff Schlotz said in a news release from the journal’s publisher.

The results are special cause for concern in relation to low-income families, where a mother’s nutritional health receives a low priority, and women are less likely to take folic acid supplements prior to becoming pregnant.

More information

The U.S. National Library of Medicine has more about folate.

— Robert Preidt

SOURCE: Journal of Child Psychology and Psychiatry, news release, Oct. 28, 2009

Last Updated: Nov. 03, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Restrictive Diet May Reduce ADHD Symptoms

By Serena Gordon
HealthDay Reporter

THURSDAY, Feb. 3 (HealthDay News) — A special restrictive diet may significantly reduce symptoms of attention-deficit hyperactivity disorder (ADHD) in young children, a new study suggests.

When children between the ages of 4 and 8 were placed on a diet containing no processed
foods for five weeks, ADHD symptoms diminished in 78 percent of them. And, when suspected trouble foods were reintroduced into the diet, two-thirds of the children experienced a relapse in symptoms.

“A strictly supervised restricted elimination diet is a valuable instrument to assess whether ADHD is induced by food,” wrote the study authors. “We think that dietary intervention should be considered in all children with ADHD, provided parents are willing to follow a diagnostic restricted elimination diet for a five-week period, and provided expert supervision is available,” they concluded.

Results of the study are published in the Feb. 5 issue of The Lancet.

ADHD is a common childhood disorder, according to the National Institute of Mental Health (NIMH). Children with ADHD have trouble paying attention, focusing and can be hyperactive. Parents have long suspected that sugary foods might be a culprit in inducing symptoms, but there’s not a lot of evidence to support this theory, according to the NIMH. However, food additives and preservatives have recently been singled out as possibly having an effect on children’s behavior, though the evidence isn’t yet conclusive.

Since some children have negative physical reactions to certain foods — such as eczema, asthma and gastrointestinal problems — that affect different organ systems, it has been suggested that foods may also affect the brain in a way that results in adverse behavior, according to information in the study.

To test this theory, the researchers recruited 100 children from Belgium and the Netherlands. The children were between the ages of 4 and 8, and all had been diagnosed with ADHD. Most of the children were boys.

The children were randomly assigned to one of two groups. One group was placed on the restrictive elimination diet, and the other group served as a control group and received advice on healthy eating.

The restrictive diet began with a diet called the “few foods diet,” which includes just rice, meat, vegetables, pears and water. The researchers then complemented this diet with certain foods, such as potatoes, fruits and wheat. The restrictive diet lasted for five weeks.

During the next four weeks, kids in the restricted diet group received two food challenge diets, in which certain foods were reintroduced into the diet. The researchers selected foods that were considered both low- and high-IgG foods.

IgG is an antibody made by the immune system that some alternative medicine practitioners believe is linked to food hypersensitivities; however, IgG testing is controversial among many mainstream physicians and even some naturopaths, according to background information in the study.

Some complementary medicine practices test for IgG and recommend eliminating foods high in IgG, explained Dr. Jaswinder Ghuman, who wrote an accompanying editorial in the same issue of the journal.

Forty-one children completed the restrictive phase of the diet. Of those, 78 percent had a reduction in their ADHD symptoms, compared with no improvement in the controls. Nine children (22 percent) didn’t respond to the diet. On an ADHD symptom scale that ranges from 0 to 72 points, with a higher score indicating more severe symptoms, the average reduction was 24 points, according to the study.

Thirty children who had shown a response on the restrictive diet went on to the challenge test. Nineteen of those children had a relapse in symptoms on the challenge test. What’s more, it didn’t appear to matter if the children with challenged with a low- or high-IgG food.

“Measuring IgG levels in kids doesn’t seem helpful,” Ghuman said, but it does look as if the elimination diet may help some children.

“If parents have noticed that a child’s behavior seems to get worse with certain foods, it may be worth considering,” said Ghuman, who is an associate professor of psychiatry and pediatrics at the University of Arizona in Tucson.

“But, for this diet to work, you have to be very consistent with it, and you have to pay attention to nutrition. It should be done under the supervision of a primary care doctor, and if possible, a dietician,” she advised.

Ghuman said that this study doesn’t answer a number of questions, such as whether or not the elimination diet reduces symptoms long-term. And, she added, that clinical practice shouldn’t be changed based on the results of one study.

Dr. Andrew Adesman, chief of developmental and behavioral pediatrics at the Steven and Alexandra Cohen Children’s Medical Center of New York in New Hyde Park, echoed Ghuman’s concerns.

“Since none of the children stayed on the diet beyond five weeks, it is hard to know if this dietary intervention offers sustained benefit,” he said, adding, “Since it is more difficult to enforce restricted diets in older children, this approach may not be suitable for the majority of older children with ADHD.”

Adesman also pointed out that this study is only applicable to children with ADHD, not to children who had ADD without the hyperactivity component.

More information

Learn more about ADHD from the National Institute of Mental Health.

SOURCES: Jaswinder Kaur Ghuman, M.D., associate professor, psychiatry and pediatrics, University of Arizona, Tucson; Andrew Adesman, M.D., chief, developmental and behavioral pediatrics, Steven and Alexandra Cohen Children’s Medical Center of New York, New Hyde Park; Feb. 5, 2011, The Lancet

Last Updated: Feb. 04, 2011

Copyright © 2011 HealthDay. All rights reserved.

CDC: Childhood ADHD Rate Rises 22%

WEDNESDAY, November 10 (Health.com) — Nearly 1 in 10 children in the U.S. has been diagnosed with attention deficit hyperactivity disorder (ADHD), and the rate appears to be growing, according to a report released today by the Centers for Disease Control and Prevention (CDC).


The percentage of children ages 4 to 17 who have ever been diagnosed with ADHD rose from 7.8% to 9.5% between 2003 and 2007—a 22% increase, the CDC found. The report was based on the results of the National Survey of Children’s Health, a nationwide telephone survey of parents.

The increases were especially dramatic among 15- to 17-year-olds and Hispanics.

It’s unclear from the survey data whether the increase in diagnoses is due to an actual rise in ADHD cases stemming from social or environmental factors, or to growing awareness of the disorder, the researchers say.

Susanna Visser, an epidemiologist at the CDC and the lead author of the report, says that factors including lead exposure, low birth weight, and premature birth have all been shown to contribute to ADHD symptoms. “This collection of risk factors could be moving in a direction that causes certain demographic groups to have higher rates of ADHD,” she says. “We have to figure out what’s driving the change.”

Getting to the root of ADHD trends will require studies that follow groups of children over time, as well as genetic and MRI studies, Visser says. Several such studies are already under way at the National Institutes for Health, she adds.

Although ADHD rates went up in all 50 states, the increases were especially striking in 12 states, including Indiana, North Carolina, and Colorado. In North Carolina—which had the highest ADHD prevalence in the nation—the rate rose from 9.6% to 15.6%, an increase of about 63%.

Those 12 states “largely account for the increase” nationwide, Visser says.

States with very high diagnosis rates included Alabama (14%), Delaware (14%), Ohio (13%), West Virginia (13%), and Arkansas (13%), in addition to North Carolina.

Roughly half of all children diagnosed with ADHD had a “moderate” or “severe” case of the disorder, and two-thirds of all children with ADHD were taking medication to control it. The estimated 2.7 million children ages 4 to 17 taking ADHD drugs represent 5% of all children nationwide in that age group, according to the report.

If parents are concerned about their child’s behavior, they should seek out information about ADHD and consult a doctor, Visser says. “There are ways to manage and control the symptoms of ADHD, through work with your doctor and with school professionals. This can be successfully managed.”

Black Henna Tattoo Chemical Can Cause Skin Reaction

THURSDAY, July 31 (HealthDay News) — Black henna tattoos contain a chemical called para-phenylenediamine (PPD) that can cause serious skin reactions, the American Academy of Dermatology (AAD) warns.

The popular black henna tattoos are sold everywhere from summer carnivals and open-air malls to vacation spots and cruise ships.


PPD, commonly used for black hair dye, is added to natural henna in order to increase the intensity and longevity of the temporary tattoo. The U.S. Food and Drug Administration prohibits the direct application of PPD to the skin because of known health risks. However, lack of regulation of the tattoo industry means people are getting black henna tattoos and putting themselves at risk for serious skin problems.

“Perhaps the most alarming issue we are seeing with black henna tattoos is the increase in the number of children—even children as young as four—who are getting them and experiencing skin reactions,” Dr. Sharon E. Jacob, assistant clinical professor of pediatrics and medicine (dermatology) at the University of California, San Diego, said in an AAD news release.

She was to present her findings at the AAD’s summer meeting in Chicago this week.

“Kids make up a significant portion of the population that receives temporary tattoos, because parents mistakenly think they are safe, since they are not permanent and are available at so many popular venues catering to families. In fact, nothing could be further from the truth,” Jacob said.

To date, there have been hundreds of reports of black tattoos causing allergic contact dermatitis, with reactions ranging from mild eczema to blistering and permanent scarring, she noted. Signs of an allergic reaction include redness and itching, bumps, swelling and blisters. Topical steroids can stop the allergic reaction.

Jacob added that some people can become sensitized to PPD from just one exposure and develop a lifelong sensitivity to PPD, along with an allergy that can cause a cross reaction to other compounds, including certain medications.

“Each exposure to PPD re-challenges the immune system, so each time you get a black henna tattoo or use a hair dye that contains PPD, there is an increased risk of having a reaction,” Jacob said. “Many people are sensitized to PPD, but don’t have a reaction to it. However, each time you are exposed to black henna, you increase your risk of developing a lifelong allergy to it.”

If you want to get a henna tattoo, make sure that it’s only vegetable henna, not PPD-adulterated henna.

“Unless the artist can tell you exactly what’s in the tattoo, don’t get one,” Jacob said.

More information

The AAD has more about tattoos, body piercings and other body adornments.

— Robert Preidt

SOURCE: American Academy of Dermatology, news release, July 30, 2008

Last Updated: July 31, 2008

Copyright © 2008 ScoutNews, LLC. All rights reserved.

Laser Resurfacing Helps Aging Faces

TUESDAY, July 22 (HealthDay News) — Carbon dioxide laser resurfacing still seems the best way to erase telltale signs of aging on your face—and keep them away.

The technique does have a fairly high rate of complications, namely lightening of the skin color, according to authors of a study published in the July/August issue of Archives of Facial Plastic Surgery.


The finding is not entirely new. But, said Dr. Keyvan Nouri, director of dermatologic and laser surgery at the University of Miami Miller School of Medicine, “The point is basically that carbon dioxide is still a very good treatment. It does have a down time and some side effects, but it does cause a dramatic improvement in many patients that we can’t achieve with anything else out there now.”

Added study co-author Dr. Shan R. Baker, director of the Center for Facial Cosmetic Surgery at the University of Michigan Medical Center: “There’s nothing earth-shattering about this paper except the fairly long-term follow-up. It just confirms that carbon dioxide laser resurfacing is very effective for deeper facial wrinkles, and it’s long-lasting.”

The laser works by absorbing water inside and outside of sells, causing heat damage to nearby tissue. As a result, the skin produces more of the protein collagen, filling in wrinkles.

“It basically causes a controlled burn to the skin,” Nouri explained. “Then it removes the epidermis [top layer of the skin] and dermis [middle layer of the skin]. It also causes contraction or tightening of the skin.”

The authors of the study described the experiences of 47 patients who underwent full-facial carbon dioxide laser resurfacing at the University of Michigan. Forty-two of the patients were women; the average age was 52.

After more than two years of follow-up, participants’ “wrinkle scores” improved 45 percent and were consistent across the face.

The main long-term complication was hypopigmentation (loss of skin color), notably present in 13 percent of patients. One case of hyperpigmentation (patches of skin that become darker) righted itself within two years of treatment.

Some patients also developed milia, small cysts or acne. One participant developed an infection, and one had sagging of the eyelids.

“The biggest problem with CO2 is lightening of the skin. Essentially all of our patients got lightening to some degree, but a certain percentage got marked lightening where you could see quite a bit of difference on photographs,” Baker said. “That’s the cost of getting rid of wrinkles permanently or near-permanently.”

“Part of it has to do with how aggressive you are with peeling,” he added. “If there are more wrinkles, you have to do more energy levels, and you often do more than two or three passes, so the patients are going to get more lightening. The deeper you go, the more lightening you are going to get.”

According to Nouri, today’s treatments tend to be less aggressive than in the past, so healing is faster.

The lightening tended to be consistent across the face, but there was a demarcation between the color of the skin of the face and that of the neck.

“That’s why we peel down below the jaw line to try to hide it in the shadow,” Baker said.

More information

The Cleveland Clinic has more on carbon dioxide laser resurfacing.

SOURCES: Shan R. Baker, M.D., director, Center for Facial Cosmetic Surgery, University of Michigan Medical School, Livonia; Keyvan Nouri, M.D., professor of dermatology and director of dermatologic and laser surgery, University of Miami Miller School of Medicine; July/August 2008, Archives of Facial Plastic Surgery

By Amanda Gardner
HealthDay Reporter

Last Updated: July 22, 2008

Copyright © 2008 ScoutNews, LLC. All rights reserved.

New Drug Extends Life a Bit in Advanced Prostate Cancer

MONDAY, May 16 (HealthDay News) — For men with advanced hormone-resistant prostate cancer who have also failed chemotherapy, the new drug Zytiga (abiraterone acetate) along with the steroid prednisone appears to increase survival modestly, a new study reports.

Based on data from the ongoing clinical trial, Zytiga was approved by the U.S. Food and Drug Administration in April. It works by inhibiting the production of the male hormone testosterone, which promotes the growth of cancer cells. In this regard, the drug mimics hormone therapy.

“Abiraterone prolonged overall survival in this patient population that had extremely limited therapeutic options after chemotherapy,” lead researcher Dr. Fred Saad, chief of urology at Notre-Dame Hospital in Montreal, Canada, said during a Monday morning press conference.

Men taking the drug combination had an average survival of 14.8 months, compared with 10.9 months for men taking a placebo.

“Abiraterone represents a valuable treatment option for patients with metastatic, castration [hormone]-resistant prostate cancer who had been treated previously with chemotherapy, with very manageable treatment-related toxicity,” Saad said.

The study findings were scheduled to be presented Monday at the American Urological Association’s annual meeting, in Washington D.C. Because the study was presented at a meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

The study included 1,195 men with prostate cancer who did not respond to hormone therapy and had failed earlier chemotherapy. The researchers, from 147 hospitals across 13 countries, randomly assigned the men to take either Zytiga plus prednisone, or a placebo.

The drug combination was well tolerated and resulted in less fatigue, back pain and spinal compression among the men taking it, compared with the placebo, Saad said.

The most common side effects among those taking Zytiga and prednisone were lower levels of white blood cells, fluid retention, low potassium levels, abnormal liver function tests, high blood pressure and heart problems, the researchers noted.

A one-month supply of 120 pills of Zytiga costs $5,000, said Kelly McLaughlin, a spokeswoman for the maker of the drug, Centocor Ortho Biotech Inc., and sponsor of the study.

“This study tells us that there is a form of hormonal therapy, abiraterone, that works in people who had standard hormonal therapy and chemotherapy,” said prostate cancer expert Dr. Anthony D’Amico, chief of genitourinary radiation oncology at Brigham and Women’s Hospital in Boston.

“It will provide people with late-stage disease with an opportunity for an extended survival that they didn’t have before. I can’t say it’s a home run because it’s only a few months improvement,” he added.

Very aggressive prostate cancer may be able to make its own testosterone, which the cancer cells need to grow. “Zytiga blocks that,” D’Amico explained.

“This drug provides longer life and better quality of life to men with very advanced prostate cancer,” D’Amico said. “There are studies now to see if this drug will improve cure rates in men with advanced, but not metastatic [cancer that has spread to other organs], prostate cancer,” he added.

More information

For more on prostate cancer, visit the American Cancer Society.

SOURCES: Anthony D’Amico, M.D., Ph.D., chief, genitourinary radiation oncology, Brigham and Women’s Hospital, Boston; Kelly McLaughlin, spokeswoman, Centocor Ortho Biotech Inc., Horsham, Penn.; May 16, 2011, teleconference with Fred Saad, M.D., director of urologic oncology and professor of surgery/urology, University of Montreal, chief of urology at Notre-Dame Hospital, University of Montreal, Canada; May 16, 2011, presentation, 2011 American Urological Association annual meeting, Washington D.C.

Last Updated: May 16, 2011

Copyright © 2011 HealthDay. All rights reserved.

By Steven Reinberg
HealthDay Reporter