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Hormone Replacement Might Relieve Arthritis

TUESDAY, March 30 (HealthDay News) — Hormone replacement therapy directed to joint fluid may help regenerate damaged cartilage tissue in people with advanced osteoarthritis, according to German researchers.

Their study aimed to examine the regenerative potential of a type of cell — chondrogenic progenitor cells, or CPCS — that is present in the late stages of osteoarthritis. The researchers speculated that these cells might be influenced by the sex hormones estrogen, which has been shown to affect bone metabolism, and testosterone.


They analyzed tissue samples from 372 men and women with arthritis who’d had a total knee replacement. Most were in their early 70s.

In the joint fluid of the participants, they found 17 beta-estradiol, a form of estrogen, which they said increases calcium deposition in both sexes. And, in the osteoarthritic tissue, they found CPCs positive for estrogen receptors and androgen receptors.

The researchers, also found that unique CPCs were present in the cartilage of people with late-stage osteoarthritis (OA).

“We were able to isolate CPCs in 95.48 percent of female patients and 96.97 percent of male patients, making these cells a good target for future therapeutic intervention for a very large number of OA patients,” Dr. Nicolai Miosge, from August University in Goettingen, said in a news release from Wiley-Blackwell, which publishes Arthritis & Rheumatism.

The findings are reported in the journal’s April issue.

“Hormone replacement therapy in joint fluid may help mitigate the effects of OA,” Miosge concluded, adding that further investigation was needed.

More information

The Arthritis Foundation has more about osteoarthritis.

— Robert Preidt

SOURCE: Wiley-Blackwell, news release, March 30, 2010

Last Updated: March 30, 2010

Copyright © 2010 HealthDay. All rights reserved.

High-Impact Sports Might Not Harm Knee Replacements

FRIDAY, March 12 (HealthDay News) — Patients who get a total knee replacement are usually advised to avoid high-impact sports to preserve their new body part. But a new study suggests sport participation is not only safe — it may even help people gain better knee function.

”Initially, we though high-impact sports were terrible for the prosthesis,” said Dr. Sebastien Parratte, a research collaborator at the Mayo Clinic in Rochester, Minn., and an assistant professor at the Aix-Marseille University Center for Arthritis Surgery at Hospital Sainte-Marguerite in Marseille, France.


“Our eight-year results have shown it is not the case,” he said.

He is the lead author of the study, scheduled for presentation Friday at the annual meeting of the American Academy of Orthopaedic Surgeons in New Orleans.

More than a half million total knee replacements are performed annually in the United States, according to the American Academy of Orthopaedic Surgeons. Parratte and his colleagues conducted the study knowing that patients routinely ignore their doctor’s advice to take it easy after receiving a knee replacement. In fact, about one of six patients engage in high-impact activities post-implantation, experts say.

Parratte’s team followed 535 patients in all. A total of 218 underwent knee replacement and then performed heavy manual labor or engaged in a non-recommended sport, such as high-impact aerobics, football, soccer, baseball, jogging or power lifting. The control group of 317 patients had knee replacement but did not engage in sports that were not recommended.

The researchers evaluated the patients clinically and with X-rays. About eight years after surgery, they found no significant radiological differences and no significant differences in the implant durability between groups.

In fact, the sport group had slightly higher knee function scores than the control group.

A first comparison found that the control group had a 20 percent higher need to repeat the operation because of mechanical failure of the knee (from wear, fracture or loosening) compared to the sport group. But when they took into account other health problems such as obesity or diabetes, the sport group had a 10 percent higher risk of mechanical failure compared to the control group, but the difference wasn’t statistically significant.

”The control group was more likely to have high blood pressure, obesity and diabetes,” Parratte added.

He said he doesn’t know why the sport group’s knees held up better.

Still, the study findings are no reason to tell patients with knee replacements to exercise in a high-impact way, said Dr. Christian Christensen, an orthopedic surgeon and head of adult reconstruction at the Lexington Clinic in Lexington, Ky.

“I think it’s a good study and certainly a worthwhile one,” he said. “Would it encourage me to tell my patients to play football? No way.”

More research is needed to evaluate what’s happening, he said. It’s possible that the people with the best results may be the ones engaging in high-impact sports. “People with the knees that feel great, who have excellent results,” are perhaps the ones who can engage in the high-impact sports without ill effect, he said.

Another possibility, he said, is that the follow-up may just not be long enough, that ill effects may show up later. Christensen said he’ll continue to tell his knee-replacement patients to avoid high-impact sports. “Implants aren’t meant to tolerate high-impact sports,” he said.

Dr. Benjamin Bengs, another expert, called the new study findings promising. It shows these devices are long-lasting, can lead to lifelong pain relief and excellent functioning and activity in patients, said Bengs, an orthopedic surgeon at Santa Monica-University of California Medical Center and Orthopaedic Hospital.

But more time and study are needed before we completely release people to all high-impact activities, he said.

”One study is not enough to change the recommendations,” Parratte agreed. He plans to study the topic further.

More information

To learn more about total knee replacement, visit the American Academy of Orthopaedic Surgeons.

By Kathleen Doheny
HealthDay Reporter

SOURCES: Sebastien Parratte, M.D., Ph.D., orthopedic surgeon, Mayo Clinic, Rochester, Minn., and Aix-Marseille University, Center for Arthritis Surgery, Hospital Sainte-Marguerite, Marseille, France; American Academy of Orthopaedic Surgeons annual meeting, March 12, 2010, New Orleans; Christian Christensen, M.D., head of adult reconstruction at the Lexington Clinic, Lexington, Ky.; Benjamin Bengs, M.D., orthopedic surgeon, Santa Monica–University of California Medical Center and Orthopaedic Hospital, Santa Monica, Calif., and assistant professor, orthopedic surgery, UCLA David Geffen School of Medicine, Los Angeles

Last Updated: March 12, 2010

Copyright © 2010 HealthDay. All rights reserved.

Low Vitamin D Levels Tied to Obesity in Kids

FRIDAY, April 29 (HealthDay News) — Vitamin D deficiency is common in American children and linked with obesity and different types of fat distribution in white and black youngsters, new research shows.

Vitamin D is found in certain foods, but humans synthesize most of the nutrient they need via the action of sunlight on exposed skin. Supplements can also boost levels of vitamin D.

In the study, researchers checked vitamin D levels in 237 healthy obese and non-obese white and black children, aged 8 to 18. They found that most of them were vitamin D deficient. Low levels of vitamin D were associated with higher body mass index and fat levels, and lower levels of “good” high-density lipoprotein (HDL) cholesterol.

Among those with vitamin D deficiency, white children were more likely to have higher levels of fat between their internal organs (visceral adipose tissue), while black children were more likely to have higher levels of fat just under the skin (subcutaneous adipose tissue), the investigators found.

The study is published in the May issue of the Journal of Clinical Endocrinology & Metabolism.

“Vitamin D deficiency is rampant in American youth, and there is some suggestion in adults that low levels of vitamin D may be playing a role in the increasing rates of type 2 diabetes. It is possible the same may be true for youth with type 2 diabetes,” lead author Dr. Silva Arslanian, of the University of Pittsburgh, said in a news release from the Endocrine Society.

“Besides therapeutic interventions to correct the high rates of vitamin D deficiency in youth, benefits of vitamin D optimization on fat levels, lipid [blood fat] profile and risk of type 2 diabetes need to be explored,” Arslanian added.

More information

The American Academy of Pediatrics has more about children and vitamin D.

– Robert Preidt

SOURCE: The Endocrine Society, news release, April 27, 2011

Last Updated: April 29, 2011

Copyright © 2011 HealthDay. All rights reserved.

Tall, Obese Men More Prone to Leg Clots: Study

By Randy Dotinga
HealthDay Reporter

THURSDAY, April 28 (HealthDay News) — Men who are both obese and tall face a much higher risk for developing potentially fatal blood clots, though overall the risk remains quite small, according to a new study.

The researchers report that extra weight and extra inches together seem to raise the risk more than either alone.


“Tall and obese men had more than a fivefold higher risk, compared to short and lean men,” said the study’s co-author, Sigrid K. Braekkan, who warns the vertically and horizontally gifted to avoid sitting in one place for too long.

Women also face a higher risk if they’re both obese and tall, but just being tall alone doesn’t seem to be a problem, the study found.

The clots lead to a condition known as deep vein thrombosis, which may be best known as an affliction that strikes passengers on long plane flights who don’t have much chance to move around. Immobilization of the legs can contribute to the condition.

Other causes include injury and a genetic condition that makes people’s blood more likely to clot. “And there are some people who seem to get clots when they don’t have any clear, obvious risk factors,” said Dr. Victor Tapson, director of the Center for Pulmonary Vascular Disease at Duke University.

Though the clots start in the leg, they can move to the lung, where they may cause a deadly pulmonary embolism. Venous thromboembolism is the term used to describe the two conditions — deep vein thrombosis and pulmonary embolism — together.

In the new study, published online April 28 in Arteriosclerosis, Thrombosis and Vascular Biology, researchers collected data on 26,714 people from 1994 to 2007, including 461 reports of venous thromboembolism.

Obese and tall men — those at least six feet tall — had more than five times the risk for a clot, compared with normal-weight men shorter than 5 feet 7 inches. The risk was three times higher for women who were obese and at least 5 feet 6 inches than for normal-weight women shorter than 5 feet 3 inches.

The higher risk for tall people appears to be related to their circulatory system. “The distance for blood to return to the heart and lungs is longer,” Braekkan said. “Since the blood must be pumped upwards against the force of gravity by the calf-muscle pump, the longer distance may cause reduced flow in the legs and, thereby, higher risk of clotting.”

He said that obesity causes pressure in the abdomen that may hinder the ability of the calf-muscle pump to send blood back up into the body.

The study found, however, that the risk for developing blood clots remained low, even for the tall and obese.

But what should obese and tall people do to lower their risk even more? Until pounds can be shed, the best thing to do is to avoid situations where you’re not moving for long periods of time, Tapson said.

Even in the cramped space of a plane, try “just moving your legs, shifting your legs, going up and down on your toes and flexing your feet back and forth to keep your calf muscles stimulated,” he said. It’s also a good idea to keep hydrated (and alcohol doesn’t help on that front). Some people use elastic socks, although Tapson said they may be troublesome if they crimp the legs.

More information

The U.S. National Heart, Lung and Blood Institute has more on deep vein thrombosis.

SOURCES: Sigrid K. Braekkan, Ph.D., researcher, Hematological Research Group, University of Tromso, Norway; Victor Tapson, M.D., professor, medicine, and director, Center for Pulmonary Vascular Disease, Duke University Medical Center, Durham, N.C.; April 28, 2011, Arteriosclerosis, Thrombosis and Vascular Biology, online

Last Updated: April 28, 2011

Copyright © 2011 HealthDay. All rights reserved.

Soaring Costs Deprive Some Children of Medical Care

MONDAY, May 2 (HealthDay News) — Because of soaring health care costs in the United States, some parents are reluctant to take their children to the doctor or to buy prescription drugs, according to a new study.

Researchers examined data from 6,273 families with at least one child who took part in Medical Expenditure Panel Surveys between 2001 and 2006.

One thing that increased the chances that families would delay or go without care was excessive financial burden, defined as insurance premiums or out-of-pocket health care expenses exceeding 10 percent of family income.

Other factors were having a child with an ongoing activity limitation, and a parent with intermittent insurance.

The study also found significant racial/ethnic and income-related disparities. For example, white families were more likely than black families to report delayed or foregone care. Families with a household income below the federal poverty level were more likely to delay or go without care than those with incomes at or above 400 percent of the poverty level.

The study was to be presented Monday at the annual meeting of the Pediatric Academic Societies. Research presented at meetings is considered preliminary because it has not been subject to the scrutiny required for publication in a peer-reviewed journal.

“Every U.S. family has a finite amount of resources available to them, and every day they have to make decisions about how to allocate those resources. This is especially true in today’s economy where you hear people talk about ‘feeling the pinch,’” study leader Lauren E. Wisk, a doctoral student and graduate research assistant at the School of Medicine and Public Health, University of Wisconsin, Madison, said in an American Academy of Pediatrics news release.

“This study shows the unfortunate reality of the situation,” Wisk added. “Families aren’t choosing to spend their money on going to the doctor when someone is sick because of how much it cost them to see the doctor last time. They’re sacrificing their health because it costs too much to be healthy.”

More information

The U.S. Agency for Healthcare Research and Quality has more about health care costs.

— Robert Preidt

SOURCE: American Academy of Pediatrics, news release, May 2, 2011

Last Updated: May 02, 2011

Copyright © 2011 HealthDay. All rights reserved.

Blacks With Cancer More Inclined to Exhaust Funds to Prolong Life: Study

TUESDAY, April 26 (HealthDay News) — White patients with lung or colorectal cancer are less willing than patients of other races or ethnicities to use up their personal financial resources to prolong their life, a new study finds.

U.S. researchers analyzed data from 4,214 participants in the Cancer Care Outcomes Research and Surveillance study of patients with newly diagnosed lung or colorectal cancer.


The patients were interviewed about various aspects of their care, including their willingness to deplete their personal financial resources for life-prolonging treatment rather than receive less costly treatment that would not extend their lives as long.

Those who said they would spend all their money to live longer included 80 percent of black patients, 72 percent of Asians, 69 percent of Hispanics and 54 percent of whites.

After researchers accounted for factors such as income, disease stage, quality of life, patients’ age, patients’ perceived time left to live and other medical illnesses, the researchers determined that black patients were 2.4 times more likely than whites to say they’d exhaust their personal finances to extend life.

Hispanic and Asian patients were also less inclined to spend all of their money than blacks, but more likely than whites to do so.

The study appears online April 26 in the journal Cancer.

Further research is needed to determine the reasons for these differences among the races, said Michelle Martin of the University of Alabama at Birmingham and colleagues in a journal news release. Learning more about this issue may lead to cancer care that consistently reflects patient values and preferences, they added.

More information

The U.S. National Cancer Institute offers fact sheets about coping with cancer.

— Robert Preidt

SOURCE: Cancer, news release, April 26, 2011

Last Updated: April 26, 2011

Copyright © 2011 HealthDay. All rights reserved

Early Adversity May Shorten Child’s Life

WEDNESDAY, May 18 (HealthDay News) — Deprivation and neglect can cause premature aging of children’s chromosomes, a new study suggests.

Researchers examined DNA samples collected from institutionalized children (62 boys and 47 girls) in Romania taking part in a long-term study. Some of the children remained in the institution, while others were transferred to high-quality foster care at different ages.


Children who spent more time in an institution before age 5 had premature shortening of chromosome tips (telomeres) when they reached ages 6 to 10, the researchers found.

“The telomere is designed to protect the chromosome, so accelerating how early in life telomeres lose length correlates with shortened life span,” principal investigator Charles Nelson, director of the Laboratories of Cognitive Neuroscience at Children’s Hospital Boston, said in a hospital news release. “Children institutionalized early in life have shortened telomeres, which may lead to health consequences downstream, including premature aging.”

He and his colleagues found differences between girls and boys. The strongest predictor of telomere shortening for girls was the amount of time spent in the institution before 22 months of age. For boys, it was the amount of time spent in the institution before 54 months of age.

The study was published online May 17 in the journal Molecular Psychiatry.

Previous research has linked shorter telomere length in adults with cognitive defects and increased rates of cardiovascular disease and cancer.

“One question we are currently studying is whether telomere length can recover as a child spends more time in foster care, or whether the shortening we observed reflects a permanent change,” Nelson said.

More information

The University of Utah has more about telomeres.

– Robert Preidt

SOURCE: Children’s Hospital Boston, news release, May 17, 2011

Last Updated: May 18, 2011

Copyright © 2011 HealthDay. All rights reserved.